Master of Science in Biotechnology - Portland

Program Overview

The Master of Science in Biotechnology is an innovative, nonthesis graduate degree program. The curriculum of this professional science master’s combines advanced interdisciplinary training in biology, chemistry, chemical engineering, and pharmaceutical sciences with the development of high-value business skills critical to success in today’s dynamic workplace. Graduates are prepared to innovate, collaborate, and lead as research, managerial, or technical professionals in a wide range of biotechnology specialties. The program is taught by respected faculty who are also senior leaders in their fields. They bring extensive experience, firsthand knowledge of industry trends, and assurance that the curriculum is rigorous, current, and relevant.

Students may elect a concentration in which core courses are combined with specialization and elective study. All concentrations feature a co-op work experience with an industry, academic, or government employer. All concentrations except the biotechnology enterprise concentration include a hands-on lab experience and opportunities to take part in independent work in research labs. The following concentrations are available: agricultural biotechnology, biodefense, molecular biotechnology, process development, manufacturing and quality operations, biopharmaceutical analytical sciences, pharmaceutical technologies, scientific information management, regulatory science, and biotechnology enterprise. Students who do not elect a concentration will instead choose 11 credits of electives in place of concentration-specific courses.

All Roux Institute programs provide content relevant to the urgent and emerging needs of industry in Maine and the rapidly evolving regional, national, and global economy. Opportunities for experiential learning will be concentrated in Portland, the state of Maine, and the Northeast region. Students are encouraged to pursue co-ops and special virtual Experiential Network projects with the institute’s founding corporate partners, a group of leading employers in Maine.

  • Portland

    Location

  • Full-Time
    Part-Time

    Commitment

  • 2-3 years

    Duration of Program

Unique Features

  • The program content is designed to prepare students for the high-demand jobs and industry needs in Portland, the state of Maine, and the Northeast region.
  • 10 available concentrations.
  • Industry-aligned faculty.
  • Opportunities to participate in hands-on lab experience.
  • Co-ops in which students gain real-world work experience with a leading industry, academic, or government employer.
  • The program is delivered through a hybrid model of online and on-site learning.

Career Outlook

The multibillion-dollar biotechnology industry is diverse, growing, and filled with opportunity. Individuals with advanced scientific knowledge, intellectual flexibility, drive, and professional skills can pursue paths of innovation with the potential to meet critical healthcare and environmental challenges—and to change lives. The industry’s unparalleled growth is projected to continue in the coming years. The result is an ongoing expansion of career opportunities on every level and in every industry sector, from large pharmaceutical operations to entrepreneurial biotechnology startups.

Scholarships and aid

$52.7K

Tuition

Estimated Total Tuition

This is based on tuition rates for Academic Year 2019 - 20 and does not include any fees or other expenses. Some courses and labs have tuition rates that may increase or decrease total tuition. Tuition and fees are subject to revision by the president and Board of Trustees at any time.

Generous scholarships

The Roux Institute is offering generous scholarships in its inaugural year to select applicants through its Resilience Scholarship Program. Employees of the institute’s employer partners are eligible for an Employer Partner Scholarship. And Northeastern alumni receive a Double Husky Scholarship — a tuition discount of 25 percent.

Learn more about the Resilience Scholarship Program

Corporate tuition benefits

Many employers subsidize education for their employees. Speak with yours about any tuition benefits your company may offer.

Special military scholarships

For military veterans and servicemembers, a limited number of donor-funded scholarships are available even after all other aid has been awarded to help with commuting costs, childcare, and other costs of living.

Learn more about military scholarships

Federal aid

You can apply for federal aid grants and loans through the Free Application for Federal Student Aid, or FAFSA.

Learn about the FAFSA

Admission Requirements

  • Online application
  • Application fee
  • Unofficial transcripts for all institutions attended; official transcripts required upon acceptance of admission offer
  • Personal statement
  • Proof of English proficiency for all applicants from one of the following:
    • Degree earned or in progress at a U.S. institution
    • Degree earned or in progress at an institution where English is the only medium of instruction
    • Official exam scores from either the TOEFL iBT, IELTS, or PTE exam

Admission Dates

Please note that this program is not available for fall 2020, but will be available starting spring 2021.

Spring 2021 admissions deadline (domestic students only): December 1, 2020.

Program Curriculum

General Requirements

Master of Science in Biotechnology Core Requirements

Courses and their associated credit hours are listed below.

Required Core

BIOT 5120 - Foundations in Biotechnology3.00
Provides an interdisciplinary, state-of-the-art introduction to biotechnology. Covers the molecular foundations of biotechnology, molecular microbiology, receptor pharmacology, drug development processes, biotech process development and scale-up, drug approval and regulatory affairs, genomics, microarray analysis, proteomics, computational biology, molecular modeling, analytical biotechnology, and bioterrorism and biotechnology.
BIOT 5219 - The Biotechnology Enterprise2.00
Exposes students to a broad spectrum of concepts and issues that are common to biotechnology companies. Provides an overview of innovation, intellectual property, planning, government regulation, and strategic alliances. Introduces biotechnology entrepreneurship; management; and the legal aspects of science, technology, and research in the biotechnology context.
BIOT 5400 - Scientific Information Management for Biotechnology Managers0.00
Introduces biotechnology students to scientific information management specifically related to the biotechnology field. Covers an introduction to data sciences, its history, and how it is relevant to biotech today. Offers students an opportunity to obtain the background needed to assess and use modern data management capabilities such as "the cloud," big data, etc. Covers recent developments in origination of data, metadata, data models, data management, and organization and storage of data in biotechnology.
BIOT 5631 - Cell Culture Processes for Biopharmaceutical Production3.00
Covers the principles and concepts involved in the development of mammalian and other types of cell culture processes for the manufacturing of biopharmaceutical products such as monoclonal antibodies and recombinant proteins. Topics include protein expression and clone generation, batch and perfusion processes and media development, bioreactor operations and scale-up, and innovations in cell culture processes. Regulatory concepts include quality assurance in a cGMP environment.
BIOT 6214 - Experimental Design and Biostatistics2.00
Explores the principles of experimental design and statistical analysis. Emphasizes research in the molecular and biological sciences and biotechnology. Topics include probability theory, sampling hypothesis formulation and testing, and parametric and nonparametric statistical methods.
BIOL 6299 - Molecular Cell Biology for Biotechnology3.00
Integrates biochemistry and molecular biology in the cellular context. Includes the organization and replication of genomes, principles and methods for genetic manipulation, the regulation of gene expression, and the structure and function of organelles. Emphasizes protein synthesis, including translation, post-translational modifications, and translocations of proteins within the cells and secretion.
CHEM 5620 - Protein Chemistry3.00
Describes proteins (what they are, where they come from, and how they work) in the context of analytical analysis and molecular medicine. Discusses the chemical properties of proteins, protein synthesis, and the genetic origins of globular proteins in solution, membrane proteins, and fibrous proteins. Covers the physical intra- and intermolecular interactions that proteins undergo along with descriptions of protein conformation and methods of structural determination. Explores protein folding as well as protein degradation and enzymatic activity. Highlights protein purification and biophysical characterization in relation to protein analysis, drug design, and optimization.

Co-op

BIOT 6500 - Professional Development for Co-op0.00
Introduces the cooperative education program. Offers students an opportunity to develop job-search and career-management skills; to assess their workplace skills, interests, and values and to discuss how they impact personal career choices; to prepare a professional resumé; and to learn proper interviewing techniques. Explores career paths, choices, professional behaviors, work culture, and career decision making.
BIOT 6964 - Co-op Work Experience0.00
Provides eligible students with an opportunity for work experience. May be repeated without limit.

Elective List

Complete electives from the following list and/or 1-credit BUSN graduate-level courses. Electives not on this list may be chosen with faculty advisor approval.

BINF 6308 - Bioinformatics Computational Methods 14.00
Offers the first semester of a two-semester sequence on the use of computers in bioinformatics research. Offers students an opportunity to work with current methods and computational algorithms used in contemporary sequence analysis. Teaches practical skills necessary to manage and mine the vast biological information being generated and housed in public databases. Emphasizes the use of Python as the primary computer language and requires students to learn and understand basic computer logic and syntax, including an introduction to scalars, arrays, hashes, decision statements, loops, subroutines, references, and regular expressions. A focus on fundamental skills, including the command line interface found in the Linux operating system, is designed to prepare students for second-semester applications.
BIOE 5430 - Principles and Applications of Tissue Engineering4.00
Applies the principles of biology and biomedical engineering to the creation of artificial organs for transplantation, basic research, or drug development. Requires integration of knowledge of organic chemistry, cell biology, genetics, mechanics, biomaterials, nanotechnology, and transport processes to create functional organs. Reviews basic cell culture techniques, structure function relationships, cellular communication, natural and artificial biomaterials, and the basic equations governing cell survival and tissue organization.
BIOE 6000 - Principles of Bioengineering1.00
Covers the fundamentals of bioengineering research topics and methodology for master’s-level bioengineering students. Internal and external speakers discuss general topics in bioengineering, including the medical device qualification and regulatory environment, tissue engineering, cell engineering, mechanobiology, drug delivery, bioimaging, neuromotor control, and effective design of experiments. Each student is expected to read, critically evaluate, and present research in a peer-reviewed bioengineering journal article.
BIOL 5307 - Biological Electron Microscopy4.00
Presents techniques of electron microscopy applied to biological materials. Discusses specimen preparation, fixation, thin-sectioning, staining, operation of the microscopes, photographic techniques, and interpretation of electron micrographs. Requires student seminars and project.
BIOL 5499 - Plant Biotechnology4.00
Designed as an introductory course on plant biotechnology for upper-level undergraduates and first-year graduate students. Using examples from current research, offers students an opportunity to review the technology used to modify and improve economically important plants for sustainable agriculture as well as for the production of pharmaceutical and medicinal products. Specific topics include principles of plant heredity and genetics (molecular biology), plant breeding and improvement, hormones and growth regulators, gene isolation, plant tissue culture and transformation, plant-based pharmaceutical production, and stress tolerance and improvement. The course consists of weekly lectures, laboratory demonstrations, and review sessions of recent literature.
BIOL 5543 - Stem Cells and Regeneration4.00
Explores the biological basis of embryonic, adult, and induced pluripotent stem cells toward an understanding of their roles in development, homeostasis, and regeneration, as well as their therapeutic potential. The study of stem cells is a rapidly advancing area in biology and biomedicine. Although the biological basis of stem cells is a major focus, the course aims to put this knowledge into a biomedical context.
BIOL 5549 - Inventions in Microbial Biotechnology4.00
Offers readings and seminar-style discussion from the current literature on important inventions and practical applications in biotechnology, with a focus on drug discovery.
BIOL 5569 - Advanced Microbiology4.00
Focuses on how microorganisms develop, exchange, and regulate genes, and survive in various environments. Emphasizes experimental design and proof, particularly as related to genetic exchange, gene regulation, single and multicellular development, and cell-cell communication.
BIOL 5573 - Medical Microbiology4.00
Emphasizes host-parasite interactions: virulence, toxins, natural flora, and immunological responses; characteristics of the common bacterial, rickettsial, and protozoal infections in humans; and epidemiology, pathology, vaccines, and chemotherapy.
BIOL 5581 - Biological Imaging4.00
Illustrates imaging principles and techniques and their application to biological problems. Topics vary and may include microscopic and macroscopic approaches in areas such as cellular and neurobiology, ecology, and biochemistry.

Concentrations

Choose one from the following:

BIOT 5145 - Basic Biotechnology Lab Skills
Introduces selected key skills and techniques central to life sciences research. Combines hands-on training in basic laboratory skills with lecture and live demonstration. Laboratory exercises highlight the importance of precision/accuracy in dispensation of liquids and in the preparation of solutions and standards, documentation and record keeping, and maintaining a safe and sterile work environment while performing scientific research.
BIOT 6100 - Agricultural Biotechnology
Explores the key agricultural biotechnology (agritech) principles and methods that are used in industry today; serves as a foundational course exposing students, briefly, to all aspects of agritech. Topics covered include gene transfer and genetic modification; cloning; plant biotechnology, animal science, food and ecological biotechnology; consumer concerns; safety testing; and other issues related to agritech.
BIOT 7245 - Biotechnology Applications Laboratory
Presents a laboratory course in biotechnology with a focus on cutting-edge instrumentation that is currently used in the field. Directs special attention at the practical aspects of laboratory work in this field, for example, techniques in sample preparation, procedures for protein analysis, and new bioinformatic approaches. Focuses on the emerging field of chemiproteomics, which is the study of the interaction of small molecules with the proteome, that is, the full complement of proteins expressed in an individual cell or organism. Exposes the student to hands-on experience with modern instrumentation, such as mass spectrometry and high performance liquid chromatography.
ENVR 6102 - Environmental Science and Policy Seminar 2
Critically explores fundamental and modern theory, methodologies, and practices for conserving and managing coupled social-ecological systems (SES). Focuses on science and policy of environment management through the lens of coupled SES. Historically, the majority of studies focused on human-environment interactions have typically involved measuring and describing the negative impacts of human populations and development on natural ecosystems. More recently, however, environmental science and practice have experienced a paradigm shift to where now humans and the natural environment are recognized as tightly coupled systems. From an SES perspective, humans continue to shape the structure and function of ecosystems through both stressors and stewardship. However, a key advancement is the recognition that people and their behavior are directly influenced by structure, function, and services of ecosystems.
BIOT 5810 - Cutting-Edge Applications in Molecular Biotechnology
Introduces the uses of molecular biology in a biotechnology setting. Includes a brief review of the basics and then dives into state-of-the-art molecular biology applications used in biotechnology today. These applications include stability and expression of cloned gene products, gene cloning strategies, transgenic species, mutation creation and analysis, DNA fingerprinting, PCR technology, microarray technology, gene probes, gene targeting, gene therapy, stem cell technology, antisense RNA, CAR T-cell therapy, RNA interference, and CRISPR/Cas9.
BIOT 6600 - Agents of Bioterrorism
Examines the probable weapons of biowarfare—including biological, chemical, and nuclear weapons— from several perspectives. Offers fundamental information on the biology and mechanism of action of the most important potential agents of terror and an introduction to the role of government. Topics include biological impact, detection and recognition, epidemiology, and treatment. Evaluates potential dangers and effectiveness and investigates strategies for defense against attacks by such weapons. Discusses the bioethical challenges of anti-bioterror research. Also offers students an opportunity to develop skills in scientific literacy and writing.
BIOT 6610 - Biosecurity and Bioterrorism
Examines the national and international political, legal, and policy dimensions of response to threats of bioterrorism and resurging epidemics. Explores how the interagency community works at local, tribal, state, national, and international levels to meet these growing challenges. Resurging epidemics are now gaining national attention in a way not seen for generations. These threats join the long-standing challenges of potential domestic and foreign state-sponsored biowarfare attacks and the growing awareness of the threat of bioterrorism.
PPUA 5390 - Special Topics in Public Policy and Urban Affairs
Covers special topics in public policy and urban affairs. Topics are selected by the instructor and vary from semester to semester. May be repeated up to three times for up to 12 total credits.
BIOT 5145 - Basic Biotechnology Lab Skills
Introduces selected key skills and techniques central to life sciences research. Combines hands-on training in basic laboratory skills with lecture and live demonstration. Laboratory exercises highlight the importance of precision/accuracy in dispensation of liquids and in the preparation of solutions and standards, documentation and record keeping, and maintaining a safe and sterile work environment while performing scientific research.
BIOT 7245 - Biotechnology Applications Laboratory
Presents a laboratory course in biotechnology with a focus on cutting-edge instrumentation that is currently used in the field. Directs special attention at the practical aspects of laboratory work in this field, for example, techniques in sample preparation, procedures for protein analysis, and new bioinformatic approaches. Focuses on the emerging field of chemiproteomics, which is the study of the interaction of small molecules with the proteome, that is, the full complement of proteins expressed in an individual cell or organism. Exposes the student to hands-on experience with modern instrumentation, such as mass spectrometry and high performance liquid chromatography.
CHEM 5550 - Introduction to Glycobiology and Glycoprotein Analysis
Covers the background and methods used for glycoprotein characterization. Offers students an opportunity to obtain the background needed to assess the analytical steps necessary for development of glycoprotein drugs. Analyzes regulatory issues behind glycoprotein drug development. Covers recent developments in analytical and regulatory sciences.
BIOT 6320 - Quality Management Systems and Validation
Emphasizes quality management systems (QSM) and validation as it relates to the production and processes related to pharmaceuticals, including biopharmaceuticals. Discusses the implementation of a QMS plan, to include document processes, procedures, metrics, reporting, and responsibilities, aligned with pharmaceutical and biotechnology companies’ business objectives. Emphasizes implementation, signaling problems (continual improvement), transparency, validation, and team cooperation/dynamics. Specifically discusses the International Council on Harmonisation (ICH) Q10 guidelines. Topics related to QSM may include objectives, manual, organization structural responsibilities, data management, processes, product quality, continuous improvement plans, quality instruments, and document control.
BIOT 5225 - Managing and Leading a Biotechnology Company
Covers managing projects and personnel in a technology-based organization Such activities are best carried out by those who combine the technical knowledge of their industry with the insight into the best practices for working with groups of highly educated, and often very experienced people. The biotechnology industry is strongly dependent on the concept that knowledge is always shared and ownership is collective. As the fundamental organizational mantra is teamwork, the principles of managing in this environment are key to achieving important goals. How to accomplish this and make decisions that drive innovation and success have common threads with other technology based industries, but with the added complexity of the scientific challenges facing the biotechnology industry. Restricted to students in the Bouvé College of Health Sciences and in the College of Science or by permission of the program office.
BIOT 5227 - Launching your Science: Biotechnology Entrepreneurship
Provides a foundation for making financial decisions in the biotechnology industry. Examines accounting methods, forecasting, corporate valuation, exit strategies and drug pipeline economics. Introduces concepts for marketing pharmaceutical products.
BIOT 5145 - Basic Biotechnology Lab Skills
Introduces selected key skills and techniques central to life sciences research. Combines hands-on training in basic laboratory skills with lecture and live demonstration. Laboratory exercises highlight the importance of precision/accuracy in dispensation of liquids and in the preparation of solutions and standards, documentation and record keeping, and maintaining a safe and sterile work environment while performing scientific research.
BIOT 6300 - Pharmaceutical Microbiology
Studies those microorganisms associated with the manufacture of pharmaceuticals, including biopharmaceuticals. Focuses on how to exclude microorganisms, such as exotoxins and endotoxins, from pharmaceutical processes to produce a sterile product. Considers how products react to microorganism contamination and methods of disinfection. Discusses pharmaceutical microbiology as related to clean rooms and controlled environments and methods and specifications related to microorganisms based on the United States Pharmacopeia guidelines. Lastly, discusses facility monitoring, specifically EM/critical utility testing, process monitoring, and maintenance throughout with an emphasis on what regulators expect to see in terms of data.
BIOT 6320 - Quality Management Systems and Validation
Emphasizes quality management systems (QSM) and validation as it relates to the production and processes related to pharmaceuticals, including biopharmaceuticals. Discusses the implementation of a QMS plan, to include document processes, procedures, metrics, reporting, and responsibilities, aligned with pharmaceutical and biotechnology companies’ business objectives. Emphasizes implementation, signaling problems (continual improvement), transparency, validation, and team cooperation/dynamics. Specifically discusses the International Council on Harmonisation (ICH) Q10 guidelines. Topics related to QSM may include objectives, manual, organization structural responsibilities, data management, processes, product quality, continuous improvement plans, quality instruments, and document control.
BIOT 6340 - Sterile Manufacturing Operations
Discusses the importance of sterile operations in producing drug products, as part of good manufacturing practice (GMP). Emphasizes sterile manufacturing operations for all drugs.
BIOT 7245 - Biotechnology Applications Laboratory
Presents a laboratory course in biotechnology with a focus on cutting-edge instrumentation that is currently used in the field. Directs special attention at the practical aspects of laboratory work in this field, for example, techniques in sample preparation, procedures for protein analysis, and new bioinformatic approaches. Focuses on the emerging field of chemiproteomics, which is the study of the interaction of small molecules with the proteome, that is, the full complement of proteins expressed in an individual cell or organism. Exposes the student to hands-on experience with modern instrumentation, such as mass spectrometry and high performance liquid chromatography.
BIOT 5145 - Basic Biotechnology Lab Skills
Introduces selected key skills and techniques central to life sciences research. Combines hands-on training in basic laboratory skills with lecture and live demonstration. Laboratory exercises highlight the importance of precision/accuracy in dispensation of liquids and in the preparation of solutions and standards, documentation and record keeping, and maintaining a safe and sterile work environment while performing scientific research.
BIOT 5810 - Cutting-Edge Applications in Molecular Biotechnology
Introduces the uses of molecular biology in a biotechnology setting. Includes a brief review of the basics and then dives into state-of-the-art molecular biology applications used in biotechnology today. These applications include stability and expression of cloned gene products, gene cloning strategies, transgenic species, mutation creation and analysis, DNA fingerprinting, PCR technology, microarray technology, gene probes, gene targeting, gene therapy, stem cell technology, antisense RNA, CAR T-cell therapy, RNA interference, and CRISPR/Cas9.
BIOT 5850 - Higher-Order Structure Analytics
Offers a comprehensive look at various aspects of higher- order protein structures in biotherapeutics and their implications on biological drug design. Focuses heavily on protein aggregation, a type of HOS, and analysis of those aggregates including functional implications. Topics include a review of protein structure, protein aggregation, functional aspects, and techniques to reduce HOS using protein expression and purification strategies, protein folding in disease, macromolecular crystallography, nuclear magnetic resonance, analytical ultracentrifugation, circular dichroism, light scattering, electron spin labelling, cryo-EM, WAXS, and HDX-MS. Highlights experimental design and application to the biotechnology industry in identifying and reducing HOS.
BIOT 7245 - Biotechnology Applications Laboratory
Presents a laboratory course in biotechnology with a focus on cutting-edge instrumentation that is currently used in the field. Directs special attention at the practical aspects of laboratory work in this field, for example, techniques in sample preparation, procedures for protein analysis, and new bioinformatic approaches. Focuses on the emerging field of chemiproteomics, which is the study of the interaction of small molecules with the proteome, that is, the full complement of proteins expressed in an individual cell or organism. Exposes the student to hands-on experience with modern instrumentation, such as mass spectrometry and high performance liquid chromatography.
BIOT 5145 - Basic Biotechnology Lab Skills
Introduces selected key skills and techniques central to life sciences research. Combines hands-on training in basic laboratory skills with lecture and live demonstration. Laboratory exercises highlight the importance of precision/accuracy in dispensation of liquids and in the preparation of solutions and standards, documentation and record keeping, and maintaining a safe and sterile work environment while performing scientific research.
BIOT 5640 - Drug Product Processes for Biopharmaceuticals
Covers the development and implementation of the drug product manufacturing process for biopharmaceuticals. Focuses on biologic products, specifically proteins. Covers the workflow required for the development and implementation of the production process with the scientific and engineering principles highlighted. Topics include the preformulation process for early stage product development, the selection of formulation compatible with the targeted product presentation, optimization of formulations to meet stability and usage objectives, the design of a scalable process for production, large-scale process equipment and operations, process scale-up considerations, and regulatory compliance issues for drug product manufacturing facilities and operations. Students who do not meet course prerequisites may seek permission of instructor.
BIOT 5700 - Molecular Interactions of Proteins in Biopharmaceutical Formulations
Offers an up-to-date survey and review of the research and understanding of the molecular interactions of proteins in biopharmaceutical formulations, including both liquid and solid formats, during the process of drug product manufacturing. Focuses on protein-protein interactions, protein-excipients (e.g., stabilizers, surfactants) interactions, and protein at interface surfaces interactions that are critical and impactful on the stability and integrity of therapeutic proteins of interest. Emphasizes understanding the mechanistic aspect of the interactions; the approaches, methods, and techniques employed to study these phenomena; and measures considered to modulate such interactions to enhance the performance of the biopharmaceutical formulations. Students who do not meet course prerequisites may seek permission of instructor.
BIOT 7245 - Biotechnology Applications Laboratory
Presents a laboratory course in biotechnology with a focus on cutting-edge instrumentation that is currently used in the field. Directs special attention at the practical aspects of laboratory work in this field, for example, techniques in sample preparation, procedures for protein analysis, and new bioinformatic approaches. Focuses on the emerging field of chemiproteomics, which is the study of the interaction of small molecules with the proteome, that is, the full complement of proteins expressed in an individual cell or organism. Exposes the student to hands-on experience with modern instrumentation, such as mass spectrometry and high performance liquid chromatography.
BIOT 5145 - Basic Biotechnology Lab Skills
Introduces selected key skills and techniques central to life sciences research. Combines hands-on training in basic laboratory skills with lecture and live demonstration. Laboratory exercises highlight the importance of precision/accuracy in dispensation of liquids and in the preparation of solutions and standards, documentation and record keeping, and maintaining a safe and sterile work environment while performing scientific research.
BIOT 5560 - Bioprocess Fundamentals
Focuses on the fundamental principles and elements in the process of manufacturing biopharmaceuticals. Covers kinetics of enzymatic reactions; selected microbial and cell metabolism and relevant control mechanisms; kinetics of cell growth, cell death, substrate consumption, and product formation; mathematical modeling and representation of bioprocesses; examples of industrial bioprocesses to illustrate types and operations of upstream and downstream unit operations and mass transfers in fermentation systems—the affecting factors and the impact on process development and scale-up. Also includes an overview of economic considerations. Emphasizes bioprocesses for recombinant protein production.
BIOT 5635 - Downstream Processes for Biopharmaceutical Production
Addresses the development of recombinant protein purification processes in biotechnology. Provides an overview of the scientific principles, engineering strategies, and unit operations facilities involved in scalable protein purification processes. Also discusses viral clearance and inactivation strategies; cGMP considerations; and technological advances to improve effectiveness and efficiency, such as membrane-based disposable systems.
BIOT 7245 - Biotechnology Applications Laboratory
Presents a laboratory course in biotechnology with a focus on cutting-edge instrumentation that is currently used in the field. Directs special attention at the practical aspects of laboratory work in this field, for example, techniques in sample preparation, procedures for protein analysis, and new bioinformatic approaches. Focuses on the emerging field of chemiproteomics, which is the study of the interaction of small molecules with the proteome, that is, the full complement of proteins expressed in an individual cell or organism. Exposes the student to hands-on experience with modern instrumentation, such as mass spectrometry and high performance liquid chromatography.
BIOT 5145 - Basic Biotechnology Lab Skills
Introduces selected key skills and techniques central to life sciences research. Combines hands-on training in basic laboratory skills with lecture and live demonstration. Laboratory exercises highlight the importance of precision/accuracy in dispensation of liquids and in the preparation of solutions and standards, documentation and record keeping, and maintaining a safe and sterile work environment while performing scientific research.
BIOT 5330 - Drug Safety and Immunogenicity
Introduces the fundamental molecular interactions involved in immunological responses as well as in measuring and testing in a research and regulated environment. Other drug-safety-related topics include adventitious agents (viruses, microorganisms, mycoplasma) and risk factors such as product-related substances (aggregates and post-translationally modified variants), endotoxins, DNA, host-cell proteins, process contaminants such as antibiotics, and the means of testing and removing these through validated processes.
BIOT 5500 - Concepts in Regulatory Science
Introduces the science that supports regulatory affairs in the biopharmaceutical industry. Focuses on the methods and instruments used to characterize the processes and products of biotechnology including the production, separation, purification, characterization, and formulation of biologics; the pharmacokinetics of proteins; chemical and biological equivalencies of biogenerics; stability testing; high throughput assays; cell system expression; variants; method validation; and quality control.
BIOT 6320 - Quality Management Systems and Validation
Emphasizes quality management systems (QSM) and validation as it relates to the production and processes related to pharmaceuticals, including biopharmaceuticals. Discusses the implementation of a QMS plan, to include document processes, procedures, metrics, reporting, and responsibilities, aligned with pharmaceutical and biotechnology companies’ business objectives. Emphasizes implementation, signaling problems (continual improvement), transparency, validation, and team cooperation/dynamics. Specifically discusses the International Council on Harmonisation (ICH) Q10 guidelines. Topics related to QSM may include objectives, manual, organization structural responsibilities, data management, processes, product quality, continuous improvement plans, quality instruments, and document control.
BIOT 5340 - Introduction to Biotherapeutic Approvals
Introduces students to biologics. The class of drugs referred to as biologics or biotherapeutics, proteins drugs, makes up a large portion of the drugs in development and on the market today. Focuses on considerations for approval for such drugs. Offers students an opportunity to learn how to be able to describe and explain both biologics and biosimilars.
BIOT 7245 - Biotechnology Applications Laboratory
Presents a laboratory course in biotechnology with a focus on cutting-edge instrumentation that is currently used in the field. Directs special attention at the practical aspects of laboratory work in this field, for example, techniques in sample preparation, procedures for protein analysis, and new bioinformatic approaches. Focuses on the emerging field of chemiproteomics, which is the study of the interaction of small molecules with the proteome, that is, the full complement of proteins expressed in an individual cell or organism. Exposes the student to hands-on experience with modern instrumentation, such as mass spectrometry and high performance liquid chromatography.
BIOT 5145 - Basic Biotechnology Lab Skills
Introduces selected key skills and techniques central to life sciences research. Combines hands-on training in basic laboratory skills with lecture and live demonstration. Laboratory exercises highlight the importance of precision/accuracy in dispensation of liquids and in the preparation of solutions and standards, documentation and record keeping, and maintaining a safe and sterile work environment while performing scientific research.
BIOT 7245 - Biotechnology Applications Laboratory
Presents a laboratory course in biotechnology with a focus on cutting-edge instrumentation that is currently used in the field. Directs special attention at the practical aspects of laboratory work in this field, for example, techniques in sample preparation, procedures for protein analysis, and new bioinformatic approaches. Focuses on the emerging field of chemiproteomics, which is the study of the interaction of small molecules with the proteome, that is, the full complement of proteins expressed in an individual cell or organism. Exposes the student to hands-on experience with modern instrumentation, such as mass spectrometry and high performance liquid chromatography.
DA 5020 - Collecting, Storing, and Retrieving Data
Studies how to build large-scale information repositories of different types of information objects so that they can be selected, retrieved, and transformed for analytics and discovery, including statistical analysis. Analyzes how traditional approaches to data storage can be applied alongside modern approaches that use nonrelational data structures. Through case studies, readings on background theory, and hands-on experimentation, offers students an opportunity to learn how to select, plan, and implement storage, search, and retrieval components of large-scale structured and unstructured information repositories. Emphasizes how to assess and recommend efficient and effective large-scale information storage and retrieval components that provide data scientists with properly structured, accurate, and reliable access to information needed for investigation.
DA 5030 - Introduction to Data Mining/Machine Learning
Introduces the fundamental techniques for data mining, combining elements from CS 6140 and CS 6220. Discusses several basic learning algorithms, such as regression and decision trees, along with popular data types, implementation and execution, and analysis of results. Lays the data analytics program foundation of how learning models from data work, both algorithmically and practically. The coding can be done in R, Matlab or Python. Students must demonstrate ability to set up data for learning, training, testing, and evaluating.
INSH 5301 - Introduction to Computational Statistics
Introduces the fundamental techniques of quantitative data analysis, ranging from foundational skills—such as data description and visualization, probability, and statistics—to the workhorse of data analysis and regression, to more advanced topics—such as machine learning and networks. Emphasizes real-world data and applications using the R statistical computing language. Analyzing and understanding complex data has become an essential component of numerous fields: business and economics, health and medicine, marketing, public policy, computer science, engineering, and many more. Offers students an opportunity to finish the course ready to apply a wide variety of analytic methods to data problems, present their results to nonexperts, and progress to more advanced course work delving into the many topics introduced here.
BIOT 5145 - Basic Biotechnology Lab Skills
Introduces selected key skills and techniques central to life sciences research. Combines hands-on training in basic laboratory skills with lecture and live demonstration. Laboratory exercises highlight the importance of precision/accuracy in dispensation of liquids and in the preparation of solutions and standards, documentation and record keeping, and maintaining a safe and sterile work environment while performing scientific research.
BIOT 7245 - Biotechnology Applications Laboratory
Presents a laboratory course in biotechnology with a focus on cutting-edge instrumentation that is currently used in the field. Directs special attention at the practical aspects of laboratory work in this field, for example, techniques in sample preparation, procedures for protein analysis, and new bioinformatic approaches. Focuses on the emerging field of chemiproteomics, which is the study of the interaction of small molecules with the proteome, that is, the full complement of proteins expressed in an individual cell or organism. Exposes the student to hands-on experience with modern instrumentation, such as mass spectrometry and high performance liquid chromatography.

Experiential Learning

Learning integrated with professional experience is a hallmark of Northeastern and the Roux Institute. Students gain a clear understanding of real-world industry needs in Portland, the state of Maine, and the Northeast—and valued workplace skills like communication and teamwork—through assignments at companies and nonprofit organizations. Students can complete a six-week virtual project relevant to their studies through the university’s Experiential Network (XN) of employers. Or they can apply for four- and six-month, full-time co-op positions. All opportunities enable students to build their resumés, expand their professional networks, and chart a path to in-demand careers.   

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